Spontaneous renal tumors in two rats from a thirteen week rodent feeding study with grain from molecular stacked trait lepidopteran and coleopteran resistant (DP-ØØ4114-3) maize
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Highlights
► A thirteen week feeding study was conducted by feeding Sprague Dawley rats diets containing grain from DP-ØØ4114-3 maize. ► DP-ØØ4114-3 maize grain was either untreated (4114) or treated in the field with glufosinate ammonium. ► Amphophilic-vacuolar (AV) renal tubule tumors were observed in two male rats consuming diets containing 4114 maize grain. ► An expert panel of pathologists was convened as a Pathology Working Group (PWG) to review the kidney histology sections. ► The unanimous opinion of the PWG was that the lesions were spontaneous and not related to consumption of 4114 diets.
Keywords
Amphophilic-vacuolar tumors
Sprague-Dawley rats
13 Week feeding study
Biotechnology
Pathology Working Group
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