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Central Blood Pressure Waves Assessment: A Validation Study of Non-invasive Aortic Pressure Measurement in Human Beings

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Abstract

Introduction

Measurement of central (aortic) systolic blood pressure has been shown to provide reliable information to evaluate target organ damage. However, non-invasive central blood pressure measurement procedures are still under analysis.

Aim

To compare human pressure waveforms invasively obtained in the aorta, with the corresponding waveforms non-invasively recorded using an oscillometric device (Mobil-O-Graph).

Methods

In this research were included 20 subjects in which invasive percutaneous coronary interventions were performed. They were 10 males (68 ± 12 y. o., BMI: 27.4 ± 4.6 kg/m2) and 10 females (77 ± 8 y. o., BMI: 28.5 ± 5.3 kg/m2). During the invasive aortic pressure recording, a synchronized non-invasive Mobil-O-Graph acquisition beat by beat and reconstructed central pressure wave was performed. Both, invasive and non-invasive pressure waves were digitized and stored for subsequent analysis and calculations. A computerized interpolation procedure was developed in our laboratory to compare these pressure waves.

Results

A significant correlation between Mobil-O-Graph central blood pressure measurements and the corresponding invasive values was found in males (r < 0.81; p < 0.01) and females (r < 0.93; p < 0.01). However, in both genders, the slope of the regression lines was lesser than 1 (males: y = 0.7354x + 18.998; females: y = 0.9835x + 2.8432). In the whole population (n = 20), a significant correlation between Mobil-O-Graph central blood pressure measurements and the corresponding invasive values was found (r < 0.89; p < 0.01) and the regression line was lesser than 1 (y = 0.9774x + 1.7603).

Conclusions

In this research, a high correlation between invasive central blood pressure values and those measured with the Mobil-O-Graph device was found in males, females and the whole population. However, a sub estimation of Mobil-O-Graph central blood pressure values was observed.

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Acknowledgements

This work was supported by the René Favaloro University Foundation, Buenos Aires, Argentina.

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Authors and Affiliations

  1. Metabolic Unit and Hypertension Unit, University Hospital, Favaloro Foundation, Buenos Aires, Argentina

    Ramiro Sánchez, Micaela Mirada & Agustín Ramírez

  2. IMETTYB Favaloro University-CONICET, Solís 453 (1078), Buenos Aires, Argentina

    Franco Pessana, Agustín Ramírez & Edmundo Cabrera Fischer

  3. Department of Information Technology, Engineering and Exact Sciences Faculty, Favaloro University, Buenos Aires, Argentina

    Franco Pessana

  4. Electronic Department, Buenos Aires Regional Faculty, National Technological University, Buenos Aires, Argentina

    Franco Pessana & Gabriel Lev

  5. Hemodynamic Department, University Hospital, Favaloro Foundation, Buenos Aires, Argentina

    Oscar Mendiz

Authors
  1. Ramiro Sánchez
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  2. Franco Pessana
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  4. Micaela Mirada
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Correspondence to Franco Pessana.

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No funding was received.

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All authors have no conflicts of interest or financial ties to disclose.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and their later amendments or comparable ethical standards.

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Sánchez, R., Pessana, F., Lev, G. et al. Central Blood Pressure Waves Assessment: A Validation Study of Non-invasive Aortic Pressure Measurement in Human Beings. High Blood Press Cardiovasc Prev 27, 165–174 (2020). https://doi.org/10.1007/s40292-020-00371-4

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  • DOI: https://doi.org/10.1007/s40292-020-00371-4

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