1 Revista Brasileira de Reumatologia 2008 Vol: 48(5):. DOI: 10.1590/S0482-50042008000500011

Necrose digital em paciente com lúpus eritematoso sistêmico e esclerose sistêmica tratada com inibidores da fosfodiesterase

The phosphodiesterase inhibitors have been used recently for the treatment of Raynaud's phenomenon and digital ischaemia. We report the case of a patient affected by systemic lupus erythematosus and limited systemic sclerosis who presented severe Raynaud's phenomenon with digital necrosis despite treatment. The patient presented an excellent response to the association of immunosuppressant therapy and sildenafil.

  1. Casale R, Generini S, Luppi F, et al.: Pulse cyclophosphamide descreases sympathetic postganglionic activity, controls alveolitis, and normalizes vascular tone dysfunction (Raynaud's phenomenon) in a case of early systemic sclerosis. Arthritis Rheum. 51 , 665-9 (2004) .
  2. Sunderkötter C, Riemekasten G: Vasoactive therapies in systemic sclerosis. Rheumatology 4 , 49-51 (2006) .
  3. Fries R, Shariat K, von Wilmowsky H, Böhm M: Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy. Circulation 112 , 2980-5 (2005) .
  4. Levien TL: Phosphodiesterase inhibitors in Raynaud's phenomenon. Ann Pharmacother 40 , 1388-93 (2006) .
  5. Kumana CR, Cheung GTY, Lau CS: Severe digital ischaemia treated with phosphodiesterase inhibitors. Ann Rheum Dis 63 , 1522-4 (2004) .