1 2004 Vol: 44(1). DOI: 10.1590/S0482-50042004000100009

Capilaroscopia periungueal: importância para a investigação do fenômeno de Raynaud e doenças do espectro da esclerose sistêmica

Nailfold capillaroscopy is a noninvasive method useful for the evaluation of microcirculation morphologic component. It allows an early differential diagnosis between subjects with primary Raynaud's phenomenon and patients with secondary Raynaud's phenomenon. In systemic sclerosis and sclerodermaspectrum syndromes there are capillaroscopic findings easily distinguished from the pattern of healthy controls, and characterized by the presence of enlarged loops, avascular areas and diffuse loss of capillaries. Because of their diagnostic relevance, the acquaintance of internists and rheumatologists with nailfold capillaroscopy is of utmost importance.

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References
  1. Silva LSM, Lima ARAG, Pucinelli MLC, Atra E, Andrade LEC: Capilaroscopia panorâmica periungueal e sua aplicação em doenças reumáticas. Rev Ass Med Brasil 43 , 69-73 (1997) .
  2. Maricq HR, LeRoy EC: Patterns of finger capillary abnormalities in connective tissue disease by "wide-field" microscopy. Arthritis Rheum 16 , 619-28 (1973) .
  3. Maricq HR, LeRoy EC, D,Angelo WA, et al: Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders. Arthritis Rheum 23 , 183-189 (1980) .
  4. Maricq HR, Harper FE, Khan MM: Microvascular abnormalities as possible predictors of disease subsets in Raynaud's phenomenon and early connective tissue disease. Clin Exp Rheumatol 1 , 195-205 (1982) .
  5. Andrade LEC, Atra E, Pucinelli ML, Ikedo F: Capilaroscopia periungueal: proposição de uma nova metodologia e aplicação em indivíduos hígidos e portadores de enfermidades reumáticas. Rev Bras Reumatol 30 , 71-81 (1990) .
  6. Andrade LEC, Gabriel JrA, Assad RL, Ferrari JAL, Atra E: Panoramic nailfold cappilaroscopy: a new reading method and normal range. Semin Arthritis Rheum 20 , 21-31 (1990) .
  7. Bukhari M, Hollis S, Moore T, Jayson MI, Herrick AL: Quantitation of microcirculatory abnormalities in patients with primary Raynaud's phenomenon and systemic sclerosis by video capillaroscopy. Rheumatology (Oxford) 39 , 506-12 (2000) .
  8. Grassi W, Medico PD, Izzo F, Cervini C: Microvascular involvement in systemic sclerosis: capillaroscopic findings. Semin Arthritis Rheum 30 , 397-402 (2001) .
  9. Maricq HR: Wide-field capillary microscopy. Technique and rating scale for abnormalities seen in scleroderma and related disorders. Arthritis Rheum 24 , 1159-65 (1981) .
  10. Lee P, Leung F, Alderdice C, Armstrong SK: Nailfold capillary microscopy in the connective tissue diseases: a semiquantitative assessment. J Rheumatol 10 , 930-8 (1983) .
  11. Statham BN, Rowell NR: Quantification of the nailfold capillary abnormalities in systemic sclerosis and Raynaud's syndrome. Acta Derm Venereol (Stockl) 66 , 139-43 (1986) .
  12. Ohtsuka T: Quantitative analysis of nailfold capillary abnormalities in patients with connective tissue diseases. Int J Dermatol 38 , 757-64 (1999) .
  13. Ohtsuka T, Ishikawa H: Statistical definition of nailfold capillary pattern in patients with systemic sclerosis. Dermatology 188 , 286-9 (1994) .
  14. Spencer-Green G, Crowe WE, Levinson JE: Nailfold capillary abnormalities and clinical outcome in childhood dermatomyositis. Arthritis Rheum 25 , 954-8 (1982) .
  15. Houtman PM, Kallenberg CG, Fidler V, Wouda AA: Diagnostic significance of nailfold capillary patterns in patients with Raynaud's phenomenon. An analysis of patterns discriminating patients with and without connective tissue disease. J Rheumatol 13 , 556-63 (1986) .
  16. Caspary L, Schmees C, Schoetensack I, et al: Alterations of the nailfold capillary morphology associated with Raynaud phenomenon in patients with systemic lupus erythematosus. J Rheumatol 18 , 559-66 (1991) .
  17. Furtado RN, Pucinelli ML, Cristo VV, Andrade LE, Sato EI: Scleroderma-like nailfold capillaroscopic abnormalities are associated with anti-U1-RNP antibodies and Raynaud's phenomenon in SLE patients. Lupus 11 , 35-41 (2002) .
  18. Spencer-Green G: Outcomes in primary Raynaud phenomenon: a meta-analysis of the frequency, rates, and predictors of transition to secondary diseases. Arch Intern Med 158 , 595-600 (1998) .
  19. Luggen M, Belhorn L, Evans T, Fitzgerald O, Spencer-Green G: The evolution of Raynaud,s phenomenon: a longterm prospective study. J Rheumatol 22 , 2226-32 (1995) .
  20. Priollet P, Vayssairat M, Housset E: How to classify Raynaud,s phenomenon. Am J Med 83 , 494-8 (1987) .
  21. Masi AT, Rodnan GP, Medsger Jr TA, et al: Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 23 , 581-90 (1980) .
  22. LeRoy EC, Medsger Jr. TA: Criteria for the classification of Early Systemic Sclerosis. J Rheumatol 28 , 1573-6 (2001) .
  23. Lonzetti LS, Joyal F, Raynauld JP, et al: Updating the American College of Rheumatology preliminary classification criteria for systemic sclerosis: addition of severe nailfold capillaroscopy abnormalities markedly increases the sensitivity for limited scleroderma. Arthritis Rheum 44 , 735-6 (2001) .
  24. Maricq HR, Spencer-Green G, LeRoy EC: Skin capillary abnormalities as indicators of organ involvement in scleroderma (systemic sclerosis), Raynaud's syndrome and dermatomyositis. Am J Med 61 , 862-70 (1976) .
  25. Pucinelli MLC, Atra E, Sato EI, Andrade LEC: Nailfold cappilaroscopy in systemic sclerosis: correlations with involvement of lung and esophagus. Rev Bras Reumatol 35 , 136-42 (1995) .
  26. Bredemeier M: A capilaroscopia periungueal pode sugerir atividade de doença pulmonar na esclerose sistêmica. Dissertação de Mestrado, Universidade Federal do Rio Grande do Sul , (2002) .
  27. Cutolo M, Sulli A, Pizzorni C, Accardo S: Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis. J Rheumatol 27 , 155-60 (2000) .
  28. Cutolo M, Grassi W, Matucci Cerinic M: Raynaud's phenomenon and the role of capillaroscopy. Arthritis Rheum 48 , 3023-30 (2003) .
  29. Riccieri V, Rinaldi T, Spadaro A, et al: Interleukin-13 in systemic sclerosis: relationship to nailfold capillaroscopy abnormalities. Clin Rheumatol 22 , 102-6 (2003) .
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