1 Arquivos de Neuro-Psiquiatria 2003 Vol: 61(2B):. DOI: 10.1590/S0004-282X2003000300002

Is the prevalence of celiac disease increased among epileptic patients?

OBJECTIVE: To assess the prevalence of celiac disease (CD) among a group of epileptic patients attending the Epilepsy Clinics of two general hospitals in the city of Brasilia (DF), Brazil. METHOD: Serum samples were collected from 255 epileptic patients (119 children, 136 adults) originating from Epilepsy Clinics, and from a control group composed by 4405 individuals (2034 children, 2371 adults) attending the Laboratory of Clinical Analysis, for routine blood testing. The diagnosis of CD was determined by the antiendomysium antibody (IgA-EMA) test and by small intestine biopsy. RESULTS: two of the 255 epileptic patients (1:127) and fifteen subjects from the control group (1:293) tested positive for the IgA-EMA assay. CONCLUSION: the prevalence of CD was 2.3 times higher in epileptic patients than in controls (7.84 per 1000 versus 3.41 per 1000). Although still not statistically significant, this result is highly suggestive of an increased prevalence of CD among epileptic patients.

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References
  1. Littlewood JM. Coeliac disease in childhood. Baillieres Clin Gastroenterol9 , 295-327 (1995) .
  2. Shale DJ, Johnston DG, Hall R, Roberts DF. Coeliac disease in monozygotic twins. Postgrad Med J58 , 797-798 (1982) .
  3. Sollid LM, Thorsby E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology105 , 910-922 (1993) .
  4. Farrell R, Kelly CP. Current concepts: celiac sprue. N Engl J med346 , 180-188 (2002) .
  5. Meeuwisse GW. Diagnostic criteria in celiac disease. Acta Paediatr Scand59 , 461-463 (1970) .
  6. Chorzelski TP, Beutner EH, Sulej J, et al. IgA antiendomysium-antibody. A new immunological marker of dermatitis herpetiformis and coeliac disease. Br J Dermatol87 , 703-706 (1986) .
  7. Biagi F, Ellis HJ, Yiannakou JY, et al. Tissue transglutaminase antibodies in celiac disease. Am J Gastroenterol94 , 2187-2192 (1999) .
  8. Working Group of European Society of Paediatric Gastroenterology and Nutrition. Revised criteria for diagnosis of celiac disease. Arch Dis Child65 , 909-911 (1990) .
  9. Lankish PG, Martinez Schramm A, Petersen F, Dröge M, Lehnick D, Lembcke B. Diagnostic intervals for recognizing celiac disease. Z Gastroenterol34 , 473-477 (1996) .
  10. Catassi C, Fabiani E, Ratsch IM, et al. The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school-age subjects. Acta Paediatr Suppl 1996:412 , 29-35 .
  11. Carlsson A, Axelsson I, Borulf S, et al. Prevalence of IgA-antiglidin antibodies and IgA-antiendomysium antibodies related to celiac disease in children with Down syndrome. Pediatrics101 , 272-275 (1998) .
  12. Ivarsson S-A, Carlsson A, Bredberg A, et al. Prevalence of coelic disease in Turner syndrome. Acta Paediatr88 , 933-936 (1999) .
  13. Muller AF, Donelly MT, Smith CML, Grundman MJ, Holmes GKT, Toghill PJ. Neurological complications of celiac disease: a rare but continuing problem. Am J Gastroenterol91 , 1430-1435 (1996) .
  14. Fois A, Vascotto M, Di Bartolo RM, Di Marco V. Celiac disease and epilepsy in pediatric patients. Childs Nerv Syst10 , 450-454 (1994) .
  15. Cronin CC, Jackson LM, Feighery C, et al. Coeliac disease and epilepsy. Q J Med91 , 303-308 (1998) .
  16. Labate A, Gambardella A, Messina D, et al. Silent celiac disease in patients with childhood localization-related epilepsies. Epilepsia42 , 1153-1155 (2001) .
  17. Gobbi G, Bouquet F, Greco L, et al. Coeliac disease, epilepsy, and cerebral calcifications. Lancet340 , 439-443 (1992) .
  18. Ambrosetto G, Antonini L, Tassinari CA. Occipital lobe seizures related to clinically asymptomatic celiac disease in adulthood. Epilepsia33 , 476-481 (1992) .
  19. Magaudda A, Dalla Bernardina B, De Marco P, et al. Bilateral occipital calcification, epilepsy and coeliac disease: clinical and neuroimaging features of a new syndrome. J Neurol Neurosurg Psychiatry56 , 885-889 (1993) .
  20. Bye AM, Andermann F, Robitaille Y, Oliver M, Bohane T, Andermann E. Cortical vascular abnormalities in the syndrome of celiac disease, epilepsy, bilateral occipital calcifications, and folate deficiency. Ann Neurol34 , 399-403 (1993) .
  21. Souza Santos CH, Brandão de Almeida IL, Costa Gomes MD, et al. Calcificação intracraniana occipital bilateral, epilepsia e doença celíaca. Arq Neuropsiquiatr60 , 840-843 (2002) .
  22. Peltola J, Kulmala P, Isojarvi J, et al. Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy. Neurology55 , 46-50 (2000) .
  23. Wiendl H, Bien CG, Bernasconi P, et al. GluR3 antibodies: prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis. Neurology57 , 1511-1514 (2001) .
  24. Bartolomei F, Boucraut J, Barrie M, et al. Cryptogenic partial epilepsies with anti-GM1 antibodies: a new form of immune-mediated epilepsy? Epilepsia37 , 922-926 (1996) .
  25. Commission on Classification and Terminology of the International League Against Epilepsy: proposal for revised classification of epilepsy and epileptic syndromes. Epilepsia30 , 389-399 (1989) .
  26. Cook WT, Smith WT. Neurological disorders associated with adult coeliac disease. Brain89 , 683-722 (1966) .
  27. Chapman RWG, Laidlow JM, Colin-Jones D, Eade OE, Smith CL. Increased prevalence of epilepsy in coeliac disease. Br Med J22 , 250-251 (1978) .
  28. Holmes GKT. Non-malignant complications of coeliac disease. Acta Paediatr412 (Suppl) , 68-75 (1996) .
  29. Hanly JG, Stassen W, Whelton M, Callaghan N. Epilepsy and coeliac disease. J Neurol Neurosurg Psychiatry45 , 729-730 (1982) .
  30. Ambrosetto G, Antonini L, Tassinari CA. Occipital lobe seizures related to clinically asymptomatic celiac disease in adulthood. Epilepsia33 , 476-481 (1992) .
  31. Bernasconi A, Bernasconi N, Andermann F, et al. Celiac disease, bilateral occipital calcifications and intractable epilepsy: mechanisms of seizures origin. Epilepsia39 , 300-306 (1998) .
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