1 2004 Vol: 122(5):1106-1107. DOI: 10.1111/j.0022-202X.2004.22524.x

Psoriatic Arthritis and CARD15 Gene Polymorphisms: No Evidence for Association in the Italian Population

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References
  1. Borgiani P, Vallo L & D'Apice MR. et al Exclusion of CARD15/NOD2 as a candidate susceptibility gene to psoriasis in the Italian population. Eur J Dermatol (2002) 12: 540-542 , .
    • . . . In order to confirm these results in an independent population, we analyzed a dataset of 193 Italian PsA patients and 150 controls (details inBorgiani et al, 2002) . . .
    • . . . We further compared the PsA and control groups with the psoriasis patients without PsA, as previously described (Borgiani et al, 2002; Nair et al, 2001), but we failed to detect evidence for a linear correlation (Mantel—Haenszel's test of linearity: NS) . . .
  2. Dougados M, van der Linden S & Juhlin R. et al The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum (1991) 34: 1218-1227 , .
    • . . . The PsA was diagnosed according to the ESSG criteria (Dougados et al, 1991) . . .
  3. Gladman DD. Current concepts in psoriatic arthritis. Curr Opin Rheumatol (2002) 14: 361-366 10.1097/00002281-200207000-00005 , .
    • . . . Association studies have suggested an involvement of the major histocompatibility complex (MHC) in PsA susceptibility (Gladman et al, 2002) . . .
  4. Hugot J-P, Chamaillard M, Zouali H & Lesage S. Association of NOD2 leucine rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 411: 599-603 10.1038/35079107 , .
    • . . . The CARD15 gene has convincingly been shown to confer susceptibility to Crohn's disease in Caucasians (MIM 266600) (Hugot et al, 2001) . . .
  5. Karason A, Gudjonsson JE & Upmanyu R. et al A susceptibility gene for psoriatic arthritis maps to chromosome 16q: Evidence for imprinting. Am J Hum Genet (2003) 72: 125-131 10.1086/345646 , .
    • . . . Recently, a genome-wide linkage scan in PsA, using 1000 microsatellite markers in 178 patients with PsA from 39 families, revealed a LOD score of 2.17 on chromosome 16q (Karason et al, 2003) . . .
  6. Moll JM & Wright V. Familial occurrence of psoriatic arthritis. Ann Rheum Dis (1973) 32: 181-201 , .
    • . . . The precise etiology of PsA is unknown but a large epidemiological study in the United Kingdom reported strong familial clustering of PsA (Moll and Wright, 1973) . . .
  7. Nair RP, Henseler T & Jenisch S. et al Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan. Hum Mol Genet (1997) 6: 1349-1356 10.1093/hmg/6.8.1349 , .
    • . . . Interestingly, this region contains a psoriasis susceptibility locus (Nair et al, 1997) . . .
  8. Nair RP, Stuart P & Ogura Y. et al Lack of association between NOD2 3020 InsC frameshift mutation and psoriasis. J Invest Dermatol (2001) 117: 1671-1672 10.1046/j.0022-202x.2001.01620.x , .
  9. Nevitt GJ & Hutchinson PE. Psoriasis in the community; prevalence, severity and patient's beliefs and attitudes toward the disease. Br J Dermatol (1996) 135: 533-537 10.1046/j.1365-2133.1996.d01-1035.x , .
    • . . . Psoriasis (MIM* 177900) is a chronic inflammatory skin disorder affecting approximately 2% of the Caucasian population (Nevitt and Hutchinson, 1996) . . .
  10. Rahman P, Bartlett S & Siannis F. et al CARD15: A pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritis. Am J Hum Genet (2003) 73: 677-681 10.1086/378076 , .
    • . . . A recent study demonstrated that CARD15 polymorphisms are significantly associated to PsA, providing evidence for a possible involvement of CARD15 in the pathogenesis of PsA (Rahman et al, 2003a, b). . . .
    • . . . This sample was screened for allelic and genotypic frequencies using the same CARD15 polymorphisms (R702W, G908R and leu1007finsC) investigated byRahman et al (2003a, b) . . .
  11. Rahman P, Jones A & Curtis J. et al The Newfoundland population: A unique resource for genetic investigation of complex disease. Hum Mol Genet (2003) 12: R167-R172 10.1093/hmg/ddg257 , .
    • . . . It is therefore plausible that the positive association found in this population is the result of a linkage disequilibrium due to a founder effect (Rahman et al, 2003b) . . .
  12. Reis A, Huffmeier U & Bohm B. et al Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 suggests a role in susceptibility to psoriasis arthritis rather than psoriasis vulgaris. Am J Hum Genet (2003) Suppl. 73 105 , .
    • . . . This may support the theory that PsA and Ps are disparate in their etiology (Reis et al, 2003) . . .
  13. Wright V & Moll JMH. Psoriatic arthritis. In: Wright V, Moll JMH (eds)Seronegative polyarthritis (1976) Amsterdam: North Holland Publishing p 169-223 , .
    • . . . Psoriatic arthritis (PsA) has been defined as an inflammatory arthritis associated with psoriasis that may affect as many as 30% of psoriasis patients (Wright and Moll, 1976) . . .
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