Skip to main content
SpringerLink
Log in

Improvement of Rosacea During Acyclovir Treatment: A Case Report

  • Research letter
  • Published:
American Journal of Clinical Dermatology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Two AM, Wu W, Gallo RL, Hata TR. Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors. J Am Acad Dermatol. 2015;72(5):749–58. doi:10.1016/j.jaad.2014.08.028 (quiz 59–60).

    Article  PubMed  Google Scholar 

  2. van Zuuren EJ, Gupta AK, Gover MD, Graber M, Hollis S. Systematic review of rosacea treatments. J Am Acad Dermatol. 2007;56(1):107–15. doi:10.1016/j.jaad.2006.04.084.

    Article  PubMed  Google Scholar 

  3. Hayaishi O. Utilization of superoxide anion by indoleamine oxygenase-catalyzed tryptophan and indoleamine oxidation. Adv Exp Med Biol. 1996;398:285–9.

    Article  CAS  PubMed  Google Scholar 

  4. Wang Y, Liu H, McKenzie G, Witting PK, Stasch JP, Hahn M, et al. Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med. 2010;16(3):279–85. doi:10.1038/nm.2092.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Heyes MP, Saito K, Major EO, Milstien S, Markey SP, Vickers JH. A mechanism of quinolinic acid formation by brain in inflammatory neurological disease: attenuation of synthesis from l-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. Brain. 1993;116(Pt 6):1425–50.

    Article  PubMed  Google Scholar 

  6. Muller AC, Maharaj H, Maharaj DS, Daya S. Aciclovir protects against quinolinic-acid-induced oxidative neurotoxicity. J Pharm Pharmacol. 2005;57(7):883–8. doi:10.1211/0022357056442.

    Article  CAS  PubMed  Google Scholar 

  7. Takci Z, Bilgili SG, Karadag AS, Kucukoglu ME, Selek S, Aslan M. Decreased serum paraoxonase and arylesterase activities in patients with rosacea. J Eur Acad Dermatol Venereol. 2015;29(2):367–70. doi:10.1111/jdv.12556.

    Article  CAS  PubMed  Google Scholar 

  8. Haas J, Meyding-Lamade U, Fath A, Stingele K, Storch-Hagenlocher B, Wildemann B. Acyclovir treatment of experimentally induced herpes simplex virus encephalitis: monitoring the changes in immunologic NO synthase expression and viral load within brain tissue of SJL mice. Neurosci Lett. 1999;264(1–3):129–32.

    Article  CAS  PubMed  Google Scholar 

  9. Steinhoff M, Buddenkotte J, Aubert J, Sulk M, Novak P, Schwab VD, et al. Clinical, cellular, and molecular aspects in the pathophysiology of rosacea. J Investig Dermatol Symp Proc. 2011;15(1):2–11. doi:10.1038/jidsymp.2011.7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Sauermann G, Jaspers S, Hoppe U, Salzer B, Steinkraus V. Influence of NO-synthase antagonists in rosacea patients. J Invest Dermatol. 1997;4(108):657.

    Google Scholar 

  11. Smith JR, Lanier VB, Braziel RM, Falkenhagen KM, White C, Rosenbaum JT. Expression of vascular endothelial growth factor and its receptors in rosacea. Br J Ophthalmol. 2007;91(2):226–9. doi:10.1136/bjo.2006.101121.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Kuroki M, Voest EE, Amano S, Beerepoot LV, Takashima S, Tolentino M, et al. Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo. J Clin Invest. 1996;98(7):1667–75. doi:10.1172/JCI118962.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Lu H, Han YJ, Xu JD, Xing WM, Chen J. Proteomic characterization of acyclovir-induced nephrotoxicity in a mouse model. PLoS One. 2014;9(7):e103185. doi:10.1371/journal.pone.0103185.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Guo YJ, Luo T, Wu F, Mei YW, Peng J, Liu H, et al. Involvement of TLR2 and TLR9 in the anti-inflammatory effects of chlorogenic acid in HSV-1-infected microglia. Life Sci. 2015;127:12–8. doi:10.1016/j.lfs.2015.01.036.

    Article  CAS  PubMed  Google Scholar 

  15. Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, Bronson R, et al. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci USA. 2004;101(5):1315–20. doi:10.1073/pnas.0308057100.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Private Residence, New York, NY, USA

    Zohreh Sadat Badieyan

  2. Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA

    Sayed Shahabuddin Hoseini

Authors
  1. Zohreh Sadat Badieyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sayed Shahabuddin Hoseini
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sayed Shahabuddin Hoseini.

Ethics declarations

Funding

Sayed Shahabuddin Hoseini was supported by the National Institutes of Health/National Cancer Institute Cancer Center Support Grant P30 CA008748.

Conflict of interest

Zohreh Sadat Badieyan and Sayed Shahabuddin Hoseini have no conflicts of interest directly relevant to the content of this article.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Badieyan, Z.S., Hoseini, S.S. Improvement of Rosacea During Acyclovir Treatment: A Case Report. Am J Clin Dermatol 18, 845–846 (2017). https://doi.org/10.1007/s40257-017-0315-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40257-017-0315-8

Search

Navigation